Das multizentrische Lymphom bei 411 Hunden – eine epidemiologische Studie

Theresa Ernst; Martin Kessler; Esther Lautscham; Lisanne Willimzig; Reto Neiger

doi:10.15654/TPK-150338

Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Table of Contents

Tierarztl Prax Ausg K Kleintiere Heimtiere 2016; 44(04): 245-251
DOI: 10.15654/TPK-150338

Originalartikel

Schattauer GmbH

Das multizentrische Lymphom bei 411 Hunden – eine epidemiologische Studie

Multicentric lymphoma in 411 dogs – an epidemiological study

Theresa Ernst

¹Tierarztpraxis Dr. Ernst, Stuttgart

,

Martin Kessler

²Tierklinik Hofheim, Hofheim

,

Esther Lautscham

²Tierklinik Hofheim, Hofheim

,

Lisanne Willimzig

²Tierklinik Hofheim, Hofheim

,

Reto Neiger

³Klinik für Kleintiere, Justus-Liebig-Universität Gießen

› Author Affiliations

Abstract

Zusammenfassung

Ziel: Überblick über die epidemiologische Situation des multizentrischen Lymphoms (ML) des Hundes in Deutschland. Material und Methoden: 411 Hunde mit ML wurden retrospektiv hinsichtlich Rasse,Körpergewicht und des Anteils der Hunde mit Hyperkalzämie bzw. T- und B-Zell-Lymphom ausgewertet und statistisch mit zwei Vergleichspopulationen verglichen (Klinikpopulation Tierklinik Hofheim, n = 52142; krankenversicherte Hunde, n = 123423). Ergebnisse: 298 (72, 5%) der 411 Hunde gehörten 86 verschiedenen Rassen an, 113 (27, 5%) waren Mischlinge. Bei Gegenüberstellung mit beiden Vergleichspopulationen zeigte sich übereinstimmend eine Rasseprädisposition für American Pitbull Terrier (Quotenverhältnis [QV] 5, 2 bzw. 18, 5), American Staffordshire Terrier (QV 3, 3 bzw. 4, 6), Briard (QV 5, 6 bzw. 9, Bullmastiff (QV 7, 8 bzw. 5, 0), Irish Setter (QV 3, 1) und Rottweiler (QV 2, 8 bzw. 3, 6). Golden Retriever (n = 22, QV 1, 3 bzw. 0, 9) und Berner Sennenhunde (n = 22, QV 2, 4 bzw. 2, 0) waren in absoluten Zahlen häufig vertreten, doch ergab sich beim Vergleich mit den Vergleichspopulationen lediglich ein QV < 3. Das durchschnittliche Körpergewicht betrug 30, 2 ± 13, 7 kg, nur 75 (18%) Hunde wogen weniger als 15 kg. Bei den kleineren Hunden (< 15 kg KM) waren West Highland White Terrier (n = 12) gehäuft vertreten. Das mittlere Alter der Hunde lag bei 7, 9 ± 2, 7 Jahren. Hunde ≥ 15 kg waren signifikant (p < 0, 001) jünger (7, 6 ± 2, 4 Jahre) als Hunde < 15 kg (9, 3 ± 3, 2 Jahre). Hunde mit B-Zell-Lymphom hatten ein signifikant (p < 0, 001) höheres Alter (8, 5 ± 2, 6 Jahre) als Hunde mit T-Zell-Lymphom (6, 4 ± 1, 8 Jahre). Eine Geschlechtsprädisposition ließ sich nicht nachweisen (54% männlich, 46% weiblich). Eine paraneoplastische Hyperkalzämie als Zeichen eines T-Zell-Lymphoms lag bei 44 (11, 4%) Hunden vor. 20, 6% bzw. 79, 4% der Hunde wiesen einen T- bzw. B-Zell-Immunphänotyp auf. Klinische Relevanz: Bereits bekannte Rasseprädispositionen konnten bestätigt und bislang unbekannte Rassehäufungen identifiziert werden (Briard, Irish Setter). Bei kleineren Hunden (< 15 kg) tritt das ML in deutlich höherem Alter auf.

Summary

Objective: To provide an overview of the epidemiology of canine multicentric lymphoma in Germany. Material and methods: A total of 411 dogs with multicentric malignant lymphoma were retrospectively analysed regarding breed, age, sex, weight and the number of animals dogs with hypercalcaemic lymphoma and B-/T-immunophenotype, and compared to two reference populations (total own clinic population, n = 52 142; dogs with health insurance in Germany, n = 123 423). Results: In total, 298 (72.5%) of the 411 dogs belonged to 86 different breeds, while 113 (27.5%) dogs were mixed breed. In comparison to both reference populations, a breed predisposition for the American Pitbull Terrier (odds ratio [OR] 5.2 and 18.5), American Staffordshire Terrier (OR 3.3 and 4.6), Briard (OR 5.6 and 9.5), Bullmastiff (OR 7.8 and 5.0), Irish Setter (OR 3.3 and 4.1) and Rottweiler (OR 2.8 and 3.6) was found. Golden Retrievers (n = 22, OR 1.3 and 0.9) and Bernese Mountain Dogs (n = 22, OR 2.4 and 2.0) were frequently affected in absolute numbers, but when compared to the reference populations an OR < 3 was detected. Mean body weight was 30.2 ± 13.7 kg; only 75 (18%) dogs weighed < 15 kg. Amongst the small dogs (< 15 kg), there was a large number of West Highland White Terriers (n = 12). Mean age of the dogs with lymphoma was 7.9 ± 2.7 years. Dogs weighing ≥ 15 kg were significantly (p < 0.001) younger (7.6 ± 2.4 years) compared to dogs weighing < 15 kg (9.3 ± 3.2 years). Dogs with a B-cell immunophenotype (8.5 ± 2.6 years) were significantly older compared to dogs with a T-cell immunophenotype (6.4 ± 1.8 years) (p < 0.001). There was no gender predisposition (54% male, 46% female). Hypercalcaemia as an indicator of T-cell lymphoma was present in 44 (11.4%) of the dogs. A T-cell and B-cell immunophenotype was found in 20.6% and 79.4% of the dogs, respectively. Clinical relevance: This study confirms previous data about breed predispositions for canine malignant multicentric lymphoma and demonstrates that further breeds are predisposed (Briard, West Highland White Terrier, Irish Setter). Small-breed dogs (< 15 kg BM) appear to be affected with lymphoma at a greater age.

Schlüsselwörter

Alter - Geschlecht - West Highland White Terrier - Hyperkalzämie - T-Zell-Lymphom - Rasseprädisposition - Referenzpopulation

Keywords

Breed predisposition - hypercalcaemia - T-cell lymphoma - reference population

Full Text

References

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